1-Benzyl-2-pyrrolidinone NBP 2-Pyrrolidinone,1-Benzyl-(6CI,7CI,8CI) CAS 5291-77-0

Tree Chem 1-Benzyl-2-pyrrolidinone (NBP) is synthesized under advanced manufacturing control to achieve high purity and excellent color stability. With superior solvency and compatibility, it is an effective replacement for NMP and DMPA in environmentally friendly formulations.

We manufacture and supply NBP to meet diverse industrial demands, including electronic cleaning, pharmaceutical synthesis, high-performance coatings, inks, and agrochemical solvents. For orders or product support, please contact info@cntreechem.com.

Specification

Basic Information

Technical Specification

Applications

Pharmaceutical Industry

• N-Benzyl-2-pyrrolidone (NBP) is widely used in the pharmaceutical industry as a high-performance solvent, reaction medium, and intermediate. Its high boiling point, low volatility, and excellent solubility make it ideal for complex synthesis reactions. NBP enhances reaction selectivity and yield, especially in β-lactam antibiotics, quinolone antibacterials, and central nervous system drugs. It is often used as a solvent for the synthesis of cefalexin, cefradine, and other cephalosporins, as well as for antiepileptic and antihistamine intermediates.
• NBP also functions as a drug carrier and solubilizer, increasing the bioavailability of poorly soluble active ingredients by forming hydrogen bonds or molecular complexes. In transdermal drug-delivery systems, it acts as a penetration enhancer that interacts with the skin’s lipid layer, increases permeability, and improves drug absorption. Clinical tests have shown that using NBP as an enhancer can double or triple transdermal drug flux without irritation.

Agrochemical Industry

• In the agrochemical sector, NBP serves as a multifunctional solvent and co-solvent for emulsifiable concentrates (ECs), suspension concentrates (SCs), and tank-mix adjuvants. In EC formulations, NBP (0.5–10%) improves the solubility of active ingredients, stabilizes formulations, and enhances wetting and spreading properties on plant surfaces. In SCs, small amounts of NBP (0.1–5%) improve suspension stability and prevent agglomeration.
• NBP also acts as a synergistic adjuvant, increasing pesticide penetration and absorption by plant tissues. Typical tank-mix formulations include 3% NBP with surfactants and solvents, significantly enhancing contact efficiency. Additionally, derivatives of NBP are valuable intermediates in insecticide and fungicide synthesis, such as N-benzyl-3-pyrrolidone and N-benzyl-4-piperidone, which are used in developing new pesticide molecules and plant-growth regulators.

Electronics Industry

• NBP has become an essential solvent in advanced semiconductor and PCB manufacturing processes. In photoresist strippers, NBP (20–75%) combined with NMP and γ-butyrolactone effectively removes thick photoresist films (>10 μm) without corroding silicon or metal substrates. It offers excellent cleaning efficiency at 60–80 °C and meets semiconductor-grade purity requirements.
• In wafer-cleaning agents, NBP-based formulations remove organic and ionic contaminants to meet SEMI Tier 2 standards (<10 ppb metal ions). In PCB and FPC manufacturing, NBP is used for flux removal and solder mask rework, ensuring high-precision cleaning. It also serves in microelectronic component cleaning, LCD panel processing, and encapsulant preparation due to its high polarity and low volatility.

Coatings and Inks

• In coatings, NBP is a powerful co-solvent that dissolves polyimide, epoxy, and other high-temperature-resistant resins. It improves film formation, adhesion, and gloss while reducing VOC emissions. Its use in automotive and industrial coatings enhances durability, weather resistance, and surface leveling. Typical solvent blends contain 10–20% NBP to balance viscosity and drying rate.
• In printing inks, NBP functions as a solvent and additive, improving pigment dispersion, print quality, and adhesion. For specialty inks such as conductive or fluorescent systems, NBP ensures uniform filler dispersion and stable viscosity, resulting in consistent optical and electrical performance.

Textile and Dyeing Industry

• NBP plays a critical role as a dye carrier and penetrant for synthetic fibers such as aramid and polyester. Its strong solvency enables deeper color penetration and improved uniformity. In textile finishing, it enhances dye dispersion and improves fiber smoothness and flexibility. It is often used in 10–30% concentration as part of high-performance dyeing formulations.
• Additionally, NBP is utilized in finishing treatments that require controlled wetting or plasticization. Its compatibility with surfactants and polymer systems allows for stable, low-foaming solutions suitable for high-pressure or continuous-dyeing operations.

Special Cleaning and Polymer Processing

• In industrial cleaning applications, NBP is used as a component in paint strippers (40–60%) and screen-printing cleaners due to its high boiling point and excellent solubility for resins, inks, and coatings. It effectively removes thermoset coatings and polymer residues while being less aggressive than chlorinated solvents.
• In polymer processing, NBP serves as a solvent and plasticizer for polyimides, polyesters, and engineering plastics. It improves polymer solubility and facilitates film casting, molding, and recycling. It is also used in lubricant formulations as a solubilizer for performance additives and in surface-active systems as a low-foam emulsifier and stabilizer.

Storage & Handling

• Store in cool, dry, and well-ventilated areas, away from heat, sparks, and direct sunlight.
• Avoid contact with oxidizers, acids, and strong reducing agents.
• Keep containers tightly closed to prevent contamination and moisture absorption.
• Use stainless steel or coated drums for handling and transfer.
• Recommended storage temperature: below 30 °C.

Usage Notice

• Handle under ventilated conditions; avoid inhaling vapors or mist.
• Use protective gloves, goggles, and clothing when handling.
• Prevent static discharge during transfer and loading operations.
• Avoid contact with reactive substances and water in storage tanks.
• Dispose of spills or residues according to local environmental regulations.
• Pharmaceutical synthesis solvent: NBP 50–100% — high boiling, chemically stable reaction medium.
• Cephalosporin synthesis: γ-butyrolactone : benzylamine : phosphoric acid = 1 : 1.5 : 0.1 — yield ≥90%.
• Transdermal patch: API 5–15%, pressure-sensitive adhesive 30–50%, NBP 3–20%, excipients q.s. — enhances skin penetration.
• Pesticide EC: active 10–60%, solvent 30–60%, NBP 0.5–10%, emulsifier 5–15% — improves solubility and stability.
• Pesticide SC: active 1–50%, dispersant 3–10%, NBP 0.1–5%, thickener 0.1–0.5% — enhances suspension stability.
• Photoresist stripper: NBP 20–75%, NMP 45–55%, BLO 35–40%, chelating agent 5–10%, water 20–40% — removes thick photoresists safely.
• Wafer cleaner: NBP 5–20%, glycol ether 10–30%, surfactant 2–11%, water balance — meets high-purity cleaning standards.
• Automotive coating: resin 40–60%, pigment 10–30%, NBP 10–20%, solvent 10–20%, additives 2–5% — improves gloss and durability.
• Printing ink: pigment 10–25%, resin 20–40%, NBP 15–25%, solvent 20–30%, additives 2–5% — enhances dispersion and flow.
• Textile dye bath: dye 2–8%, NBP 10–30%, auxiliaries 5–10%, water balance — increases color depth and uniformity.
• High-temperature paint remover: NBP 40–60%, co-solvent 20–40%, stripping agent 10–20%, surfactant 2–5% — effectively removes heat-resistant coatings.

Packaging

• 180 kg galvanized iron drum
• Customized packaging available upon request