1-Benzyl-2-pyrrolidinone NBP CAS 5291-77-0
- CAS: 5291-77-0
- Synonyms: 1-Benzyl-2-pyrrolidinone; N-Benzyl-2-pyrrolidone
- EINECS No.: 226-131-5
- Molecular Formula: C11H13NO
- Grade: Superior Grade / First Grade / Qualified Grade
- Packaging: 25 kg fiber drum with PE liner
Other than commodity solvents or general purpose intermediates, N-Benzyl-2-pyrrolidinone is commonly purchased for certain processes where molecule structure and purity directly affect reaction performance. Manufacturers with pyrrolipinone must maintain moisture and stable color to guarantee consistency.
Tree Chem produces N- Benzyl-3-pyrsrolidincone for fine chemical production, dye chemistry, and specialty organic synthesis.Small volume research material or regular industrial production is used to provide material suitable for practical manufacturing, rather than laboratory usage. Technical information and purchase information is available at info@cntreechem.com.
Specification
Basic Information
| Item | Value |
| Product Name | N-Benzyl-2-pyrrolidinone |
| Abbreviation | NBP |
| CAS No. | 5291-77-0 |
| EINECS No. | 226-131-5 |
| Molecular Formula | C11H13NO |
| Molecular Weight | 175.23 |
| Synonyms | 1-Benzyl-2-pyrrolidinone; N-Benzyl-2-pyrrolidone |
Technical Specification
| Item | Superior Grade | First Grade | Qualified Grade |
| Purity (%) | ≥99.5 | ≥99.0 | ≥98.5 |
| Water (%) | ≤0.2 | ≤0.3 | ≤0.5 |
| Color (Hazen) | ≤25 | ≤30 | ≤50 |
Applications
Pharmaceutical Intermediate Applications
- N-Benzyl-2-pyrrolidone is a pharmaceutical and fine chemical intermediate. It is a pyrrolide ring mixed with a benzyl-substituted nitrogen, and thus is often used in nitrogen-containing heterocyclic compounds. It has a lot of potential in a particular application by chemists because it can be broken down into a few downstream intermediates.
- It can be used in synthesis work as a raw material, for preparation of amine derivatives or other cyclic products. Lactam groups provide a place for further reaction, benzyl groups sometimes give solubility and reaction. Because of that it is found quite often in route exploration and small batch research. Compared to a common solvant, or simple pyrolidone products, it is usually used for synthesis instead of direct use; it is generally treated as an upstream intermediate instead of a active drug ingredient.
Fine Chemical Synthesis
- In fine chemicals, N-Benzyl-2-pyrrolidone can be reduced, substituted, or other organic reactions. Such a material may be used to prepare benzyl-substituted pyrrolidine and related intermediates.
- One of the reasons chemists do this is that in many cases they can obtain the reaction pathway straightforward. The carbonyl group can be transformed under suitable conditions and the benzyl group will remain.
- Of course, the true results always depend on the process and reaction conditions. For custom synthesis projects, customers usually are interested in purity, water, impurity, and batch stability. Price is also often the first factor checked.
Agrochemical Intermediate Development
- N-Benzyl-2-pyrrolidone can also appear in agrochemical intermediate study. Many pesticide and crop protection molecules contain nitrogen heterocyclic structures, so compounds of this kind can be tested during route design. The principal advantage here is synthetic flexibility.
- The molecule may be able to add a nitrogen ring to larger structures and leave room for further modification. Because of that, it is more suitable as an intermediate than a finished agro product. From a commercial point of view it should not be a product of agriculture, or of active activity. In fact it may be better to call it agro chemical intermediate.
Specialty Organic Solvent and Reaction Medium
- Because of its polar lactam content, N-Benzyl-2-pyrrolidone can sometimes be used as a reaction medium in some organic synthesis systems. In many cases it is found to be well suited to polar substrates and special reaction mixtures.
- It is not commonly used by NMP, DMF or DMSO, mostly because they are not used in lab work, process screening or special reactions in which the compound might provide a benefit. Users may need to check recovery and compatibility and impurity before a larger scale operation. There may be other systems that do not work here.
Material and Polymer Research
- Material research: N-Benzyl-2-pyrrolidone can be assessed if a polar organic compound is required in formulation or synthesis studies. The pyrrolitone part can be used in many organic systems and sometimes on the benzyl group can be compatible to aromatic materials.
- Researchers may consider it as a reaction component or a processing aid or solvent as small experiments and so these are mostly developed-but not really large-volume industrial applications. This should be seen as research work rather than a market.
Dye and Functional Intermediate Synthesis
- N-Benzyl-2-pyrrolidone may also be prepared for dye intermediates and other functional organic compounds. A benzyl group and a lactam ring can be used to design synthetic routes. It is not a dye or pigment. It can sometimes be a member of a chain upstream of the chain, with more nitrogen cyclic structures to be required.
- For such applications, product quality can be important, even small impurities might influence reaction performance or purification efficiency later on.
Laboratory Research and Route Development
- Lab lab studies are often performed with N-Benzyl-2-pyrrolidone. Researchers may study reduction reactions, hydrogenation, or pyrrolidine prepared by this compound, and later in the analysis of the product.
- Laboratories may develop chromatographic methods, impurity analysis or batch comparison data on the material. Projects move from laboratory to production and often they focus on assay, moisture, appearance, storage, and supply consistency. These practical considerations become important soon.
| Application System | Typical Components or Process Design | Function of N-Benzyl-2-pyrrolidone |
| Pharmaceutical intermediate synthesis | N-Benzyl-2-pyrrolidone, reducing agent, ether-type solvent, controlled temperature conditions | Used as a lactam-type precursor to write benzyl-substituted pyrrolidine derivatives, providing a nitrogen ring structure to further develop drugs to intermediate production. |
| Amine derivative preparation | N-Benzyl-2-pyrrolidone, catalytic hydrogenation system, suitable organic solvent, purification step | It is possible to transform the pyrrolidone structure downstream amine intermediates. It would be appropriate in projects using nitrogen-containing cyclic building blocks. |
| Heterocyclic compound synthesis | N-Benzyl-2-pyrrolidone, base, electrophilic reagent, polar organic solvent | It acts as a structural scaffold for heterocyclic molecules. It provides aromatic and cyclic amide features to its target compound. |
| Agrochemical intermediate development | N-Benzyl-2-pyrrolidone, crop protection precursor, reaction solvent, catalyst or base | Applied for route screening for agrochemical intermediates in which nitrogen-containing heterocyclic structures are involved. It is preferred for intermediate production rather than directly to formulation. |
| Fine chemical custom synthesis | N-Benzyl-2-pyrrolidone, aromatic intermediate, coupling or conversion reagent, purification system | Offers a practical starting point for organic intermediates production.Its strength is reflected in structural, controlled transformation and downstream synthesis flexibility. |
| Specialty reaction medium | N-Benzyl-2-pyrrolidone, organic substrate, catalyst, temperature-controlled reaction system | It may be an acceptable polar organic reaction medium for some systems and may help to improve substrate compatibility when a common solver does not have desirable solubility or reaction. |
| Material research screening | N-Benzyl-2-pyrrolidone, resin intermediate, polar co-solvent, aromatic or heterocyclic component | Often used in small material studies where polar and aromatic compatibility is needed. It may assist dissolution, reaction contact or early formulation screening. |
| Dye intermediate synthesis | N-Benzyl-2-pyrrolidone, dye precursor, organic solvent, catalyst or functional reagent | Is an upstream intermediate of nitrogen functional molecules. should be a synthetic component instead of a finished dye or pigment. |
| Analytical method development | N-Benzyl-2-pyrrolidone, chromatographic solvent, reference standard, impurity tracking method | Used as a candidate for purity testing, assay generation and impurity profile analysis. This may be used for batch control and customer qualification. |
| Pilot-scale process evaluation | N-Benzyl-2-pyrrolidone, selected reaction system, sampling plan, moisture and impurity control | Check if the laboratory route can be transferred into a larger process. Evaluation criteria include appearance, purity, water content, impurity, reaction and storage stability. |
Why Purchasing Teams Evaluate NBP Differently
When buying N-Benzyl-2-pyrrolidinone, a decision often needs to be made based on purity.
Industrial buyers typically focus on:
- batch-to-batch consistency
- moisture control
- long-term supply availability
- packaging suitability for export shipment
- compatibility with existing manufacturing processes
As a result, many customers value NBP suppliers not only via specification sheets but also through production stability and supply reliability.
Storage & Handling
- Store in sealed containers in a cool and dry location.
- Avoid direct exposure to moisture and excessive heat.
- Keep away from oxidizing agents and incompatible chemicals.
- Maintain clean transfer equipment during handling.
- Follow standard industrial chemical safety procedures.
Packaging
- 25 kg fiber drum with inner polyethylene liner.
- Alternative packaging configurations available upon request.
- Each package marked with product name, batch number, and net weight.
Supply Information
Tree Chem supports both research-scale and industrial-scale requirements.
Available services may include:
- sample quantities for evaluation
- pilot production support
- regular export shipments
- customized packaging solutions
