EDTMPA Ethylenebis (nitrilodimethylene) tetrakisphosphonic Acid EDTMP CAS 1429-50-1

Tree Chem manufactures EDTMPA CAS 1429-50-1 for customers requiring a high-performance phosphonate chelating agent suitable for applications in industrial water treatment, chemical cleaning, electronic chemicals, and high-end fine chemical formulations. EDTMPA provides strong binding capacity toward multivalent metal ions such as Ca²⁺, Mg²⁺, and Fe³⁺, ensuring stable performance in complex system environments.

With its white crystalline powder appearance and high purity level, EDTMPA offers excellent hydrolytic stability and resistance to oxidation. Its strong sequestration and buffering capacity make it suitable for electronic-grade formulations, metal pretreatment, and other industries that require low-impurity chemical raw materials. For technical support or commercial inquiries, please contact info@cntreechem.com.

Specification

Basic Information

Technical Specification

Note: High-purity grade at 99% (chromatographic purity) is available for use in electronics and pharmaceutical industries.

Applications

Water Treatment Industry – Circulating Cooling Water and Boilers

• Ethylenediamine tetramethylene phosphonic acid (EDTMPA) is first and foremost a nitrogen-containing multiphosphonic chelating agent for industrial water treatment, especially circulating cooling-water systems and boiler water. Its structure, with four methylene phosphonic groups and one ethylenediamine core, allows multidentate coordination with Ca²⁺, Mg²⁺, Fe³⁺, Al³⁺ and other metal ions, giving very strong chelation and an outstanding “threshold effect.” Even at sub-stoichiometric levels, EDTMPA disrupts crystal nucleation and growth of calcium carbonate, calcium sulfate, barium sulfate and similar salts so that they remain dissolved or form only loose, non-adherent crystals instead of hard scale on heat-exchange surfaces.
• In industrial cooling-water systems such as cooling towers, circulating loops and heat-exchanger networks, EDTMPA is used as a core antiscalant and cathodic corrosion inhibitor. Typical use concentrations in system water are on the order of 2–10 mg/L when a 30% active product is used alone, corresponding to 10–30 mg/L of concentrated solution fed proportionally to make-up water. At these levels it maintains efficient control of CaSO₄ and other inorganic scales even at temperatures approaching 200 °C, while its cathodic-type corrosion-inhibition mechanism can deliver efficiencies several times higher than traditional inorganic polyphosphates.
• In boiler water, EDTMPA is mainly applied in low-pressure and medium-pressure boilers as an internal scale inhibitor and auxiliary corrosion inhibitor. Blends where EDTMPA is combined with HPMA (hydrolyzed polymaleic anhydride) at a mass ratio of 1:3 are widely used for drum-type boilers; dosed at a total of about 5–15 mg/L, these mixtures effectively suppress carbonate and sulfate deposition, improve heat-transfer efficiency and extend cleaning intervals. When further combined with additives such as benzotriazole (BTA), polyacrylate and zinc salts, composite formulations can be tuned to different water qualities and operating pressures, providing integrated scale and corrosion control in both boiler and associated condensate lines.

Oilfield Water Injection and Harsh-Condition Water Systems

• Oilfield water injection and high-salinity industrial water systems are another important outlet for EDTMPA. Injection waters and produced waters often contain very high levels of Ca²⁺, Ba²⁺, Sr²⁺ and other ions, and when they mix with formation waters rich in sulfate or carbonate anions, the tendency to form tenacious CaSO₄, BaSO₄ and SrSO₄ scales is very strong. EDTMPA maintains its chelating performance under high temperature and high pressure, resisting hydrolysis and retaining complexing ability in deep-well environments where many conventional chelants fail.
• In typical injection-water systems, EDTMPA is dosed at about 10–50 mg/L, with the exact level set according to hardness, saturation index and operating temperature. For wells dominated by barium-sulfate scaling, it is often used in targeted formulations where EDTMPA is combined with polyaspartic acid or similar biodegradable polymers in defined ratios to achieve strong BaSO₄ scale control. In such programs EDTMPA not only prevents deposition in surface lines and downhole tubing but also protects perforations and near-wellbore regions, maintaining injectivity and production over long operating cycles.

Pulp and Paper Industry

• In the pulp and paper industry, EDTMPA functions as a metal-ion controller, antiscalant and water-quality stabilizer throughout pulping, bleaching and papermaking operations. Metal ions such as Fe³⁺, Mn²⁺ and Cu²⁺ catalyze oxidative degradation and cause yellowing and embrittlement of fibers, while hardness ions contribute to scale formation on washers, strainers, screens and heat-transfer surfaces. By binding these ions into stable complexes, EDTMPA prevents their adverse interaction with fibers and chemicals, improving sheet brightness, strength and runnability.
• During pulping and stock preparation, EDTMPA is typically introduced at 5–15 mg/L to limit the concentration of free metal ions and to stabilize process liquors. In peroxide bleaching of chemical or mechanical pulps, EDTMPA can replace EDTA or DTPA as the chelating agent in the chelation (Q) stage; dosed at roughly 0.15–0.50% on oven-dry pulp and operated at about 40–60 °C with 10–15% pulp consistency and 45–75 minutes retention, it effectively sequesters metal catalysts, reduces uncontrolled peroxide decomposition and supports higher brightness with less fiber damage. In white-water and circulation loops, dosages of about 3–10 mg/L help stabilize water chemistry, while 10–20 mg/L in combination with dispersants and corrosion inhibitors is used in evaporators and other high-fouling areas to prevent scale build-up and extend cleaning intervals.

Textile Printing and Dyeing Industry

• Textile printing and dyeing is an important application field for EDTMPA, where it is used primarily as a high-efficiency chelating agent and hydrogen-peroxide bleaching stabilizer. In dyeing processes, hardness ions and trace metals can react with dyes to form insoluble complexes, leading to color spots, streaks and shade differences; EDTMPA added at 0.5–2 g/L in the dyebath or in pre-treatment baths complexes Ca²⁺, Mg²⁺ and transition metals, keeping dyes in solution or dispersion and producing level, bright shades. In practical operation, mills often add around 2 g/L of EDTMPA-based chelating agent to the bath and circulate for 5–10 minutes before introducing dyes, which effectively conditions the liquor for trouble-free dyeing.
• As an oxygen-bleach stabilizer, EDTMPA is vital in alkaline hydrogen-peroxide bleaching of cotton and blends. In typical processes, 10–30 ppm EDTMPA is premixed with the bleach liquor along with hydrogen peroxide, caustic and other auxiliaries at pH 9–11 and about 90–100 °C. The chelant binds catalytic Fe and Cu ions, suppressing uncontrolled H₂O₂ decomposition, minimizing fiber damage and improving whiteness. In more complex pre-treatment formulations, EDTMPA is combined with specialized refining agents, surfactants and alkali to remove natural impurities and metal contaminants, giving fabrics better absorbency and dye uptake in subsequent steps.

Daily Chemical and Personal-Care Industry

• In daily chemical products, EDTMPA is valued as a low-dosage, high-performance chelating and stabilizing additive. In detergents and household cleaners, a small amount of EDTMPA or its sodium salt form can replace traditional EDTA, binding metal ions in tap water to preserve surfactant performance, prevent product discoloration and protect fragrances from metal-catalyzed oxidation. In a common dishwashing-liquid formula containing linear alkylbenzene sulfonate, AES, fatty-acid alkanolamide, nonionic surfactants, preservative, caustic and salt, about 0.1 parts of EDTMPA serves as the chelating component, helping to prevent scale and spotting on dishes as well as maintaining the formulation’s appearance during storage.
• Liquid laundry detergents use EDTMPA at about 0.1–0.5% alongside 15–25% surfactants and 10–20% co-builders, where it sequesters hardness ions, improves detergency and reduces inorganic deposits on fabrics and machine parts. In personal-care products such as shampoos, body washes, facial cleansers, lotions and creams, EDTMPA at levels around 0.05–0.2% complexes trace metals that would otherwise catalyze oxidation of oils, vitamins and fragrances, thus extending shelf life and keeping color, odor and viscosity stable. Its sodium salt is particularly common in masks, anti-aging serums, moisturizers and sunscreens, where clean label, low odor and low irritation are important formulation requirements.

Pharmaceutical and Radiopharmaceutical Applications

• In the pharmaceutical sphere, EDTMPA (particularly in its acid form EDTMPA) is widely used as a chelating ligand for radiopharmaceuticals targeting bone tissue. By coordinating radionuclide metal ions such as samarium-153, lutetium-177, rhenium-186 or yttrium-90 and exhibiting strong affinity for bone mineral, EDTMPA-based complexes deliver therapeutic or diagnostic radioactivity selectively to sites of high bone turnover. The classic example is ¹⁵³Sm-EDTMP, used for palliative treatment of bone metastasis pain, where the complex accumulates in metastatic lesions and emits β-radiation that relieves pain and suppresses tumor activity while limiting dose to soft tissue.
• Preparation of such complexes relies on EDTMPA’s outstanding chelating strength and stability. For instance, ¹⁷⁷Lu-EDTMP can be prepared by reacting about 25 mg of EDTMP with a defined quantity of ¹⁷⁷LuCl₃ solution at controlled pH around 8 and elevated temperature for roughly 30 minutes, yielding a highly stable complex suitable for clinical use. Clinical data show that EDTMPA-based radiopharmaceuticals can achieve high pain-relief rates and favorable bone metabolism responses in patients with multiple skeletal metastases, and their strong bone targeting has made EDTMPA a preferred ligand in many bone-seeking agents compared with traditional chelants such as EDTA or DTPA.

Metal Processing, Surface Treatment and Electroplating

• In metal processing, EDTMPA serves as both a multi-functional water-treatment component and a surface-conditioning agent. In recirculating cooling-water systems for rolling mills, continuous casting lines and other metallurgical equipment, its scale-inhibiting and corrosion-inhibiting properties protect heat exchangers, pipelines and spray systems, stabilizing operating conditions and reducing maintenance. As a cleaning component, EDTMPA at around 0.5–2% by mass is combined with acids such as citric acid or sulfamic acid and circulated through equipment at about 50–60 °C for 6–8 hours to remove internal water-scale and rust from boilers, heat exchangers and other process equipment, improving heat transfer and extending service life.
• In electroplating, EDTMPA acts as a key cyanide-free complexing agent for copper and alloy baths. Non-cyanide copper-plating formulations typically employ 50–200 g/L of EDTMPA or related phosphonate complexants together with 1–10 g/L Cu²⁺, small amounts of brighteners and leveling agents, and operate at pH 8–12 and moderate temperatures to deposit bright, fine-grained copper coatings without cyanide. Non-cyanide imitation-gold processes use sulfate salts of copper and zinc, optional sodium stannate, boric acid, citric acid, suitable EDTMPA-based chelators and potassium hydroxide at relatively high pH to form golden decorative deposits, eliminating cyanide and ammonia emissions and simplifying wastewater treatment.

Electronics Industry and Semiconductor Cleaning

• The electronics industry relies on high-purity EDTMPA as a critical chelating component in semiconductor wafer cleaning and precision electronics cleaning. Electronic-grade EDTMPA, with purity often above 99% and extremely low heavy-metal content, is formulated into ultra-clean aqueous solutions that remove trace metallic contaminants from wafer surfaces during integrated-circuit manufacturing. Its chelating action lifts metallic residues into solution while avoiding aggressive attack on underlying films, helping to reduce defect densities and improve device yield.
• For printed-circuit boards and assembled electronics, EDTMPA is incorporated as the chelating agent in neutral, environmentally friendly water-based cleaning agents. At concentrations around 0.2–0.5%, combined with carefully selected surfactants and pH regulators, it assists in dissolving flux residues and metal contaminants without corroding copper traces or component terminations. In applications such as copper-foil polishing and surface conditioning, EDTMPA-containing formulations enhance grinding efficiency, improve surface smoothness and reduce burr formation, contributing to better adhesion and long-term reliability of metallization and soldering steps.

Building Materials, Food and Other Emerging Uses

• In building materials, EDTMPA is used in admixture systems for concrete and mortar to improve durability and reduce cracking. By chelating calcium ions and moderating early hydration, it can be included in compound admixtures that control setting behavior, mitigate internal stress development and reduce scaling on mixing and pumping equipment, thereby enhancing the long-term performance of structures in aggressive environments. In oil-well cementing, similar principles are applied to control thickening time and maintain slurry stability under high temperatures and pressures, ensuring reliable zonal isolation and casing protection.
• The food and broad specialty-chemical sectors provide niche but growing applications for EDTMPA. In food-related formulations, carefully controlled low-dosage EDTMPA or its salts can act as chelating and anti-oxidation aids to slow discoloration and oxidative degradation, extending product shelf life under strict safety and purity standards. Looking ahead, development of greener, more biodegradable EDTMP-based derivatives and low-phosphorus or phosphorus-free composite systems is expected to support expanded use in new areas such as advanced cooling fluids for energy systems and high-end, low-residue cleaning agents, as downstream industries demand both stronger performance and improved environmental profiles.

Specification Grades and Quality Requirements

• Across these application fields, EDTMPA is supplied in a variety of grades tailored to performance and regulatory requirements. Industrial liquid products typically contain 30–50% active EDTMPA, while solid products offer active contents of 90% or higher, with total phosphonic acid, chloride, moisture and iron contents controlled within defined limits. High-purity grades can reach 96–99% active content with very low chloride (often ≤0.1%) and iron (on the order of a few mg/L), along with a 1% solution pH of ≤2.0, meeting the needs of demanding applications in electronics, pharmaceuticals and personal care. Packaging is usually in 25 kg or 250 kg plastic drums, stored in cool, shaded conditions with typical shelf lives of 6–12 months, and users are advised to select composition and purity according to the specific demands of water treatment, industrial processing or high-end specialty uses.

Storage & Handling

• Store in tightly closed bags or containers.
• Keep in cool, dry, ventilated storage conditions.
• Avoid contact with oxidizing substances and moisture.
• Use protective equipment during handling.
• Ensure grounding during transfer operations.

Usage Notice

• Avoid inhalation of powder; wear masks and protective gloves.
• Test compatibility before blending with strong oxidizers or metal salts.
• Keep material sealed to avoid moisture absorption.
• Follow local regulations for storage and transportation.
• Cooling-water scale-inhibitor program: a 30% active EDTMPA product is dosed at 2–10 mg/L in circulating cooling-water systems so that Ca²⁺ and other hardness ions remain complexed and cannot form adherent scale on heat-exchange surfaces.
• Cooling-water corrosion and scale inhibitor blend: 2–5 mg/L EDTMPA combined with 3–5 mg/L zinc sulfate in tower water provides synergistic cathodic protection and threshold scale inhibition for carbon-steel equipment.
• Low-pressure boiler internal-treatment formula: EDTMPA and HPMA are blended at a 1:3 mass ratio and added at 5–15 mg/L to prevent carbonate and sulfate scale formation in drum boilers while maintaining high thermal efficiency.
• Composite EDTMPA-based scale inhibitor: a formulation containing 12–19 parts hydroxyphosphonoacetic acid, 13–25 parts EDTMPA and 11–14 parts zinc sulfate in water is used as a multi-component antiscalant for demanding circulation systems.
• Boiler and heat-exchanger cleaning solution: 0.5–2% EDTMPA by mass is mixed with compatible cleaning aids and circulated at 50–80 °C for 6–12 hours to dissolve internal scale and rust.
• Oilfield injection-water treatment: EDTMPA is dosed at 10–50 mg/L, adjusted to water quality, to control composite sulfate and carbonate scaling in high-temperature, high-pressure injection systems.
• Barium-sulfate-scale control package: a 50 mg/L inhibitor made from three parts PASP and two parts EDTMP is applied in wells dominated by BaSO₄ scaling to protect tubing and formation pore spaces.
• Pulping metal-ion control: 5–15 mg/L EDTMPA is added to pulping circuits to bind Fe³⁺, Mn²⁺ and other metals, preventing brightness loss and fiber degradation.
• Papermaking-system water stabilization: 3–10 mg/L EDTMPA in white-water loops maintains charge balance and limits deposition, while 10–20 mg/L in combination with dispersants and corrosion inhibitors protects spray systems and evaporators from scale.
• Hydrogen-peroxide pulp-bleaching chelation stage: 0.15–0.50% EDTMPA based on oven-dry pulp is used at around 40–60 °C and 10–15% pulp consistency for 45–75 minutes to remove catalytic metal ions before bleaching.
• Textile dyeing pre-chelation: about 0.5–2 g/L EDTMPA is added to the dyebath and circulated for 5–10 minutes before dye addition to sequester hardness ions and prevent color spots and shade variation.
• Textile peroxide-bleaching stabilizer: 10–30 ppm EDTMPA premixed with hydrogen peroxide in a bath at pH 9–11 and 90–100 °C suppresses metal-catalyzed H₂O₂ breakdown and protects fiber strength.
• Refining and scouring auxiliary: a pre-treatment bath containing 2–4 g/L of a refining agent, 1–2 g/L EDTMPA and 15–30 g/L NaOH is used to remove impurities and metal ions from fabrics before dyeing.
• Radiopharmaceutical ¹⁵³Sm-EDTMP therapy: an injection prepared by complexing samarium-153 chloride with EDTMPA at an activity of roughly 37–111 MBq per kilogram body weight delivers β-radiation selectively to metastatic bone lesions for pain relief.
• Radiopharmaceutical ¹⁷⁷Lu-EDTMP preparation: 25 mg EDTMP reacted with 100 µL ¹⁷⁷LuCl₃ solution (about 12.8 MBq) at pH around 8 and 100 °C for 30 minutes yields a stable complex suitable for bone-targeted radionuclide therapy.
• Dishwashing-liquid formulation: a typical recipe with linear alkylbenzene sulfonate, AES, 6501, AEO-9, preservative, caustic, salt and water includes about 0.1 parts EDTMPA as the chelating agent to stabilize color and fragrance and limit spotting.
• Liquid laundry detergent formula: 15–25% surfactants, 10–20% auxiliary builders and 0.1–0.5% EDTMPA are combined in water so that hardness sequestration enhances cleaning and reduces scale in washing machines.
• Cosmetic formulation stabilization: shampoos, shower gels or creams incorporate 0.05–0.2% EDTMPA as a chelating stabilizer to bind trace metals and slow oxidation of oils and active ingredients.
• Non-cyanide copper-plating bath: 50–200 g/L EDTMPA or related complexant with 1–10 g/L copper ions, trace brighteners and leveling agents at pH 8–12 and 20–40 °C produces bright, compact copper deposits without cyanide.
• Non-cyanide imitation-gold plating solution: 20–25 g/L copper sulfate, 30–40 g/L zinc sulfate, up to 8 g/L sodium stannate, 20–30 g/L boric acid, 80–100 g/L citric acid, an appropriate amount of EDTMPA-based chelator and 80–110 g/L potassium hydroxide create an alkaline bath for gold-colored decorative coatings.
• Industrial equipment descaling fluid: 0.5–2% EDTMPA blended with 1.5–6% citric acid and water, circulated at 50–60 °C for 6–8 hours, removes water-scale and rust from internal surfaces of heat-exchange equipment.
• Semiconductor chip-cleaning solution: 0.1–1% ultra-pure EDTMPA in deionized water is used in wafer-cleaning steps to strip metallic contaminants and improve integrated-circuit yields.
• PCB and electronic-assembly cleaning agent: 0.2–0.5% EDTMPA with 0.5–1% surfactants and suitable pH regulators forms a neutral, environmentally friendly cleaner that removes flux residues and metal particles without damaging copper traces or components.

Packaging

• 25 kg composite woven bag
• Packaging that meets export environmental requirements
• Customized packaging available upon request