Octadecylamine A18 Fentamine A18 CAS 124-30-1

Tree Chem manufactures Octadecylamine CAS 124-30-1 for customers seeking to purchase high-purity long-chain primary amines used in surfactant production, flotation collectors, corrosion inhibitors, lubricants, and industrial auxiliaries. The product features stable purity, low color, and consistent reactivity, making it suitable for downstream quaternary ammonium salt synthesis and amine derivatives.

With excellent hydrophobicity and surface activity, Octadecylamine is widely used in textile antistatic agents, ore flotation chemicals, emulsifiers, water-treatment additives, and specialty chemicals. Its waxy or flake form ensures easy handling and uniform performance in industrial processes. For collaboration or bulk orders, please contact info@cntreechem.com.

Specification

Basic Information

Technical Specification

Applications

Pharmaceutical Industry

• Octadecylamine plays an increasingly important role in the pharmaceutical sector, especially as a building block and functional component in modern drug-delivery systems. Its long C18 hydrophobic chain and primary amine group allow it to form cationic lipids and polymer–lipid conjugates for lipid nanoparticles and liposomes. In mRNA vaccine delivery, ionizable lipids derived from octadecylamine are key components of lipid nanoparticle (LNP) systems, where the C18 tails embed in lipid bilayers and the cationic or ionizable head groups bind negatively charged nucleic acids such as mRNA or siRNA. These structures enable encapsulation, protection against degradation, targeted cellular uptake and efficient endosomal escape, which are essential for the therapeutic activity of nucleic-acid drugs.
• Beyond mRNA vaccines, octadecylamine-based lipids are used in broader gene therapy and vaccine platforms, including DNA delivery and small interfering RNA formulations. The design of C18–PEG–amine conjugates, in which a hydrophobic C18 chain is linked to a PEG segment and a terminal amine, allows self-assembly into micelles, liposomes and nanoparticles with good water solubility and biocompatibility. Octadecylamine is also used as an intermediate in synthesizing local anesthetics, where the long-chain structure improves lipid solubility and membrane permeability, thereby enhancing anesthetic potency and prolonging duration. Its quaternary ammonium derivatives act as broad-spectrum antiseptics and disinfectant actives, providing cell-membrane disruption and rapid antimicrobial action for medical-surface disinfection and healthcare environments.

Agrochemical Industry

• In the agrochemical field, octadecylamine and its ethoxylates are widely used as emulsifiers, dispersants and adjuvants in pesticide formulations. In emulsifiable concentrate (EC) systems, octadecylamine serves as a key surface-active component that lowers interfacial tension between oil and water, helping to form stable emulsions when the concentrate is diluted in spray tanks. Its long-chain hydrophobe anchors in the solvent and active phase, while the protonated amine or ethoxylated head groups interact with water, maintaining fine droplet size and preventing phase separation during storage and application.
• For wettable powders and water-dispersible granules, octadecylamine polyoxyethylene ethers are used as wetting and dispersing agents. They improve the wetting of hydrophobic pesticide particles, enhance dispersion stability and increase adhesion and spreading on plant surfaces. As synergy enhancers, these derivatives can increase the coverage and penetration of actives, allowing dose reductions and reduced environmental impact. In fertilizer production, octadecylamine is employed as an anti-caking agent in composite fertilizer coatings, where it helps inhibit moisture migration and crystal bridging between particles. Formulations that combine octadecylamine with talc, phosphate coupling agents and polyacrylate components are added during granulation to prevent agglomeration and maintain free-flowing granules throughout storage and transport.

Surfactant and Home & Personal Care Industry

• Octadecylamine is a fundamental raw material for a range of cationic and nonionic surfactants used in home and personal care products. Quaternization of octadecylamine with methylating agents yields octadecyl trimethyl ammonium chloride (OTAC, 1831), a classic cationic surfactant applied in shampoos, conditioners, fabric softeners and disinfectant formulations. In hair-care products, OTAC provides conditioning, softening and antistatic effects, improving combability and reducing flyaway, especially when combined with fatty alcohols, oils and humectants. Its antimicrobial character also contributes to scalp hygiene and product preservation in certain formulations.
• Octadecylamine ethoxylates function as nonionic surfactants with emulsifying, dispersing, solubilizing, antistatic, lubricating and corrosion-inhibiting properties. These derivatives are tailored by adjusting the number of ethylene-oxide units, which tunes hydrophilic–lipophilic balance and allows use in a variety of detergent, cleaning and personal-care systems. Amphoteric and amine-oxide derivatives arising from octadecylamine further expand its utility, enabling formulators to design products that combine mildness, foam stabilization, viscosity control and compatibility with anionic, cationic and nonionic ingredients across shampoos, body washes, conditioners and antibacterial cleansers.

Metalworking and Corrosion Protection

• In metalworking fluids, octadecylamine and its ethoxylates act as emulsifiers, lubricants and corrosion inhibitors in both synthetic and emulsion-type formulations. In fully synthetic cutting fluids, octadecylamine polyoxyethylene ethers are blended with fatty acid esters, diethanolamides, triethanolamine esters, borate esters and azole corrosion inhibitors to provide lubricity, cooling, detergency and rust prevention for ferrous metals. Their amphiphilic structure supports the formation of stable microemulsions or clear solutions that maintain performance under shear, high temperatures and contamination by tramp oil.
• In emulsion cutting fluids, octadecylamine can be reacted with triethanolamine to form amine soaps that act as potent emulsifiers for mineral oils. These soaps help generate stable oil-in-water emulsions when mixed with base oils, borates and water, supplying lubrication and rust protection in machining operations. Octadecylamine is also a highly effective vapor-phase corrosion inhibitor (VCI), used in film-forming corrosion-inhibitor formulations where it is combined with film formers, thiourea and pyridine in aqueous systems. When applied to metal surfaces or enclosed spaces, it volatilizes and adsorbs onto metal, forming a protective layer that reduces corrosion in storage and transport. Oil-soluble rust-preventive formulations incorporate octadecylamide, waxes, silicone oils and antioxidants in solvent oils to create barrier films that block moisture and oxygen.

Textile Industry

• In textile applications, octadecylamine and its polyoxyethylene ethers are used as antistatic agents, softeners and dyeing auxiliaries. As antistatic finishing agents, ethoxylated octadecylamines are formulated with glycerol, isopropanol and water to treat synthetic fibers, effectively dissipating static charge and reducing static-related processing and end-use issues. They form conductive, hygroscopic films on fiber surfaces, improving comfort, dust behavior and handling in spinning, weaving and garment manufacturing.
• As softening agents, dioctadecyl dimethyl ammonium chloride is combined with octadecylamine ethoxylates, fatty acid polyoxyethylene esters, isopropanol and water to create fabric softeners that deliver a smooth, flexible handfeel. In printing and dyeing processes, octadecylamine polyoxyethylene ethers act as leveling agents, dispersants and retarding agents that improve dye distribution, prevent uneven coloring and help control dyeing speed on various fiber types. Their nonionic character confers good compatibility with dyeing baths and auxiliaries across a wide pH and temperature range.

Plastics Industry

• In plastics, octadecylamine is an important raw material for internal antistatic agents, lubricants and mold-release additives. Reaction with ethylene oxide yields internal antistatic products such as bis(β-hydroxyethyl) derivatives, which are used in polyethylene, polypropylene, SAN, ABS and HIPS to lower surface resistivity and reduce static buildup on finished plastics. These antistatic agents migrate to the surface of the polymer over time, forming a conductive layer that dissipates charge while maintaining transparency and mechanical properties.
• Octadecylamine-based antistatic masterbatches for polypropylene are prepared by blending the amine, N,N-di(hydroxyethyl) coconut amide, borate esters, ethoxylates, glycerol esters and phosphite stabilizers into PP. When added at typical loadings in final plastics, these masterbatches significantly reduce surface resistivity and improve dust-repellent behavior. Octadecylamine itself also functions as an internal lubricant and mold-release agent in thermoplastic processing, where low dosages improve melt flow, reduce friction and help prevent sticking of parts to molds, thereby improving surface quality and lowering energy consumption.

Rubber Industry

• In the rubber industry, octadecylamine is used as a vulcanization accelerator, auxiliary antioxidant and processing aid. Its basic nitrogen and long-chain hydrophobe allow it to interact with sulfur and other accelerator systems, accelerating vulcanization and improving crosslinking efficiency. As a result, the cure time is shortened and the throughput of rubber-processing lines can be increased while the physical properties of vulcanized rubber, such as tensile strength and elasticity, are maintained or enhanced.
• As an auxiliary antioxidant and processing aid, octadecylamine helps stabilize rubber compounds against heat and oxygen, and improves the flow properties of rubber stocks during mixing and forming. By lowering Mooney viscosity and improving filler dispersion, it contributes to smoother surfaces, more uniform mechanical performance and better processing safety. In some systems it is used in combination with other fatty amines and waxes to achieve tailored processing and aging behavior.

Coatings and Inks

• Octadecylamine derivatives play multiple roles in coatings and inks as curing accelerators, dispersants, flow modifiers and anti-blocking agents. In epoxy coatings, octadecylamine is incorporated alongside epoxy resin, polyamide curing agents and solvents to accelerate curing, improve adhesion to substrates and enhance salt-spray resistance. Its primary amine group participates in crosslinking reactions, while the long aliphatic chain improves flexibility and hydrophobicity of the cured film, increasing barrier properties.
• In anti-corrosion coatings, octadecylamine and its derivatives function as dispersants for anti-corrosion pigments and as film-forming corrosion inhibitors that enhance rust protection. In printing inks, octadecylamine-derived surfactants act as pigment dispersants and flow-leveling agents, helping to achieve fine pigment dispersion, stable viscosity and smooth laydown on substrates. They also serve as anti-blocking components to prevent printed sheets from sticking together during stacking and finishing.

Paper Industry

• In the paper industry, octadecylamine polyoxyethylene ethers are used as softening agents, antistatic additives and sizing auxiliaries. Softener formulations for paper include AKD, octadecylamine ethoxylates and starch in water, providing improved handfeel, reduced stiffness and controlled antistatic behavior. The presence of octadecylamine-derived nonionics helps distribute hydrophobic agents evenly on fiber surfaces, supporting uniform softness and printability.
• As paper-sizing auxiliaries, octadecylamine derivatives contribute to water resistance and enhanced surface strength, thereby improving print quality and converting performance. Their role in combining hydrophobic sizing agents with hydrophilic fiber and starch components enables better anchoring of sizing chemicals and more efficient use of functional additives.

Mineral Flotation, Asphalt, Electronic Materials and Cosmetics

• In mineral flotation, octadecylamine is widely used as a cationic collector, particularly in reverse flotation of iron ore and in lithium-mica flotation. Its long-chain amine cation adsorbs selectively onto silicate gangue or target minerals under controlled pH and reagent regimes, enabling separation of valuable minerals from gangue. Industrial data show that appropriate grinding fineness, pH, starch dosage and octadecylamine dosage can upgrade iron concentrates from 30–40% Fe to above 65% Fe and produce high-grade lithium-mica concentrates with high recovery.
• In asphalt, octadecylamine is a key raw material for cationic asphalt emulsifiers used in high-softening-point emulsified asphalt for road construction and waterproofing. Composite emulsifier systems based on alkylamine and quaternary ammonium components provide stable emulsions and good adhesion to aggregates. In the electronics field, octadecylamine is used in cleaning agents and surface-treatment formulations for electronic components and semiconductor devices, where its amphiphilic nature helps remove organic contaminants while controlling corrosion. In cosmetics, octadecylamine-based quaternary compounds function as antistatic agents and conditioning agents in hair and skin products at low dosages, improving combability and tactile feel.

Storage & Handling

• Store in sealed containers away from heat and sunlight.
• Keep dry to avoid moisture absorption.
• Avoid contact with oxidizing substances.
• Use grounding to prevent static discharge.
• Maintain clean and dry handling equipment.

Usage Notice

• Heat gently before use if solidified below melting point.
• Avoid long-term exposure to high temperature.
• Wear standard protective equipment during handling.
• Check compatibility with reactive chemicals before blending.
• Follow local safety regulations for storage and transport.
• mRNA vaccine lipid nanoparticle formulations use ionizable lipids derived from octadecylamine at 30–50% of the total lipid content to serve as gene-delivery carriers.
• Local anesthetic formulations use tetracaine derivatives synthesized from octadecylamine as the main active ingredient to provide local anesthesia.
• Disinfectant formulations use octadecyl dimethyl benzyl ammonium chloride at 0.1–0.5% to achieve broad-spectrum antimicrobial and disinfecting performance.
• Herbicide or pesticide emulsifiable concentrates use octadecylamine at 1–2% as an emulsifying and dispersing agent to form stable emulsions.
• Wettable-powder or water-dispersible-granule pesticide formulations use octadecylamine polyoxyethylene ethers at 5–10% as wetting and dispersing agents to improve spreading and adhesion on plant surfaces.
• Fertilizer anti-caking formulations use octadecylamine at 0.1–0.3% in coating blends to prevent granule caking during storage and handling.
• Shampoo formulations use octadecyl trimethyl ammonium chloride at 0.5–1% to provide softness and antistatic conditioning for hair.
• Hair-conditioner formulations use behenyl trimethyl ammonium chloride, an octadecylamine-derived quat, at 1–2% to deliver conditioning and softness.
• Body-wash formulations use octadecyl dimethyl amine oxide at 2–5% to supply foaming and foam-stabilizing functions.
• Metalworking cutting-fluid formulations use octadecylamine polyoxyethylene ether at 1–2% to provide emulsifying, lubricating and anti-rust performance.
• Corrosion-inhibitor formulations use octadecylamine at 60–80 mg/L as a vapor-phase corrosion inhibitor to protect metal surfaces.
• Release-agent formulations use octadecylamine at 0.5–2% to improve demolding performance in rubber and metal forming.
• Textile antistatic-agent formulations use octadecylamine polyoxyethylene ethers at 20–30% to eliminate static on synthetic fibers.
• Textile softener formulations use dioctadecyl dimethyl ammonium chloride at 15–20% to impart softness and smoothness to fabrics.
• Plastic antistatic-masterbatch formulations use octadecylamine-based blends at 10–15% to reduce surface resistivity of plastic products.
• Plastic-lubricant formulations use octadecylamine at 0.1–0.5% to improve processing flow and reduce friction in polymer melts.
• Rubber vulcanization-accelerator formulations use octadecylamine at 0.5–1% to speed up vulcanization and increase curing efficiency.
• Epoxy-coating formulations use octadecylamine at 3–5% to accelerate curing and improve adhesion and salt-spray resistance.
• Paper-softener formulations use octadecylamine polyoxyethylene ethers at 5–8% to improve paper handfeel and antistatic performance.
• Mineral-flotation formulations use octadecylamine at 100–1500 g per ton of ore as a cationic collector to achieve mineral separation.

Packaging

• 160 kg iron drum
• 25 kg woven bag
• Available in waxy solid or flake form