Tri-n-octylamine TOA Trioctylamine 7301 CAS 1116-76-3

Tree Chem manufactures Tri-n-octylamine as a colorless to pale-yellow transparent liquid with reliable purity and low secondary-amine content. Its strong coordination ability and hydrophobicity make it highly efficient for non-aqueous extraction processes.

Production follows strict quality control to ensure stable performance in solvent extraction, catalysts and fine-chemical intermediates. Packaging options include 200 kg iron drums or 160 kg drums, with customized packaging available upon request. For quotations or technical consultation, contact info@cntreechem.com.

Specification

Basic Information

Technical Specification

Applications

Pharmaceutical Industry

• Tri-n-octylamine serves as a key phase-transfer catalyst and reaction promoter in antibiotic, cardiovascular, and antiviral intermediate synthesis. In fluoroquinolone routes, Tri-n-octylamine accelerates nucleophilic substitutions and shortens reaction time, while in ACE-inhibitor and calcium-channel-blocker synthesis it enhances stereochemical selectivity and intermediate conversion.
• As a functional auxiliary, Tri-n-octylamine improves emulsification, wetting, and suspension stability in pharmaceutical preparations where low-solubility actives require improved dispersion. Quaternary derivatives of Tri-n-octylamine exhibit strong antimicrobial activity and are incorporated into medical-device disinfectant solutions to provide broad-spectrum sterilization performance.
• In synthetic organic chemistry, Tri-n-octylamine enhances multiphase reaction transfer efficiency, particularly in nucleophilic substitution and condensation steps, enabling higher yields and more controlled reaction kinetics in complex pharmaceutical routes.

Agrochemical Industry

• Tri-n-octylamine is extensively used as an emulsifier and co-surfactant in herbicide formulations, forming stable oil-in-water emulsions for active ingredients such as glyphosate and acetochlor. Its long-chain tertiary-amine structure reduces interfacial tension and maintains dispersion during storage and spraying.
• In glyphosate systems, Tri-n-octylamine cooperates with polyoxyethylene surfactants, aromatic solvents, and alcohols to improve wetting and leaf penetration. In acetochlor and triazine herbicide formulations, it helps achieve finer particle distribution and more persistent field performance.
• Tri-n-octylamine enhances the synthesis of organophosphorus and pyrethroid insecticide intermediates by promoting the formation of key precursors. Its quaternary derivatives also function as synergists and disinfectant-type additives in seed treatments and foliar formulations.

Surfactant Industry

• Tri-n-octylamine is a central building block for cationic, non-ionic, and amphoteric surfactants.
• Cationic surfactants formed by quaternization of Tri-n-octylamine, such as TOMAC or TOBAC types, provide strong bactericidal, antistatic, and softening effects for industrial cleaning, textile finishing, catalysis, and phase-transfer applications.
• Ethoxylation of Tri-n-octylamine produces non-ionic surfactants with adjustable HLB values, enabling use in detergents, shampoos, cosmetic emulsions, industrial degreasers, and agrochemical emulsions where strong emulsifying and dispersing capability is required.
• Amphoteric surfactants synthesized from Tri-n-octylamine—including betaine and imidazoline derivatives—offer mildness, pH-range stability, and excellent compatibility, supporting applications in personal-care products, enhanced-oil-recovery fluids, and specialty industrial formulations.

Metalworking and Corrosion Control

• In metalworking fluids, Tri-n-octylamine functions as a pH regulator, auxiliary emulsifier, and corrosion inhibitor. In synthetic cutting fluids, it improves lubrication, cooling, and ferrous-metal passivation, while in semi-synthetic systems it balances emulsion stability with anti-rust performance.
• Tri-n-octylamine reacts with organic acids to form amine salts and amides that create protective films on metal surfaces. These compounds appear in composite rust-preventive formulations containing borates, sulfonates, and inhibitors, delivering reliable protection during machining, storage, and transport.
• In acidic, aqueous, and oilfield environments, Tri-n-octylamine exhibits both physical and chemical adsorption on metal surfaces, lowering corrosion current density and providing synergistic inhibition alongside zinc salts, phosphates, or sulfur-containing inhibitors.

Petrochemical and Oilfield Applications

• Tri-n-octylamine is involved in formulating acidizing corrosion inhibitors for oil and gas wells. Its tertiary-amine structure allows strong adsorption and film formation under high-temperature, high-acidity conditions, maintaining steel integrity during HCl-based treatments.
• As an emulsifier and stabilizer in drilling fluids, Tri-n-octylamine contributes to lubrication, shale inhibition, and filtrate control. It also serves as a precursor for surfactant systems used in enhanced-oil-recovery where reducing oil-water interfacial tension raises crude-oil displacement efficiency.
• Tri-n-octylamine-based additives appear in multiphase petrochemical processes to control acidity, stabilize emulsions, and enhance the performance of co-surfactant structures.

Rubber and Polymer Industry

• Tri-n-octylamine functions as a vulcanization accelerator and activator in natural and synthetic rubber compounds, helping disperse ZnO and sulfur and increasing cross-linking rate and mechanical strength.
• Its derivatives are used as processing aids that reduce compound viscosity during mixing and extrusion. Certain Tri-n-octylamine derivatives act as anti-aging or scorch-retardant components, improving thermal stability and extending safe processing windows.

Textile and Leather Processing

• Quaternary ammonium compounds derived from Tri-n-octylamine serve as antistatic and softening agents in synthetic-fiber processing. They reduce surface resistivity, prevent static buildup, and deliver long-lasting softness across multiple wash cycles.
• In textile dyeing, Tri-n-octylamine-based surfactants act as leveling and wetting agents to ensure uniform color distribution and enhanced penetration. For leather finishing, amide derivatives provide smoothness, hydrophobicity, and improved wear resistance.

Electronics and High-Tech Applications

• Tri-n-octylamine is a precursor for liquid-crystal intermediates used in TN, STN, and TFT-LCD displays, where its long-chain tertiary-amine structure contributes to molecular alignment and phase-behavior control.
• It is also employed in electronic cleaning formulations to remove organic residues without damaging sensitive components. In photoresist systems, Tri-n-octylamine acts as a base quencher that regulates acid diffusion, improving pattern resolution and line-edge precision.
• In lithium-ion battery electrolytes, Tri-n-octylamine enhances ionic conductivity, stabilizes SEI formation, and improves cycle performance. It additionally serves as a surface modifier in solar-cell coatings and as a template agent for nanomaterial synthesis and dispersion.

Other Industrial Uses

• In mineral flotation, Tri-n-octylamine functions as a selective collector for sulfide and oxide ores of metals such as copper, zinc, and lead, improving froth stability and recovery rate.
• Tri-n-octylamine is used as an anti-caking ingredient in fertilizer coatings to prevent clumping during storage. It also improves pigment dispersion in coatings and inks by reducing system viscosity and enhancing wetting of solid particles.
• In lubricants, Tri-n-octylamine acts as a dispersant and antioxidant precursor, helping prevent metal oxidation and extending equipment life.

Storage & Handling

• Store in sealed containers, in a cool, dry and ventilated place
• Avoid heat, sparks and direct sunlight
• Keep away from strong oxidizing agents
• Ensure adequate ventilation during handling

Usage Notice

• Avoid contact with eyes, skin and clothing
• Prevent prolonged exposure to air and humidity
• Use protective gloves and safety equipment
• Medical-device disinfectant formulation: quaternary ammonium salts derived from Tri-n-octylamine at 0.1–0.5% provide broad-spectrum sterilization for equipment soaking solutions.
• Antibiotic intermediate synthesis: Tri-n-octylamine acts as a phase-transfer catalyst to accelerate nucleophilic substitution and improve yields in fluoroquinolone routes.
• Glyphosate herbicide emulsion: 5–15% Tri-n-octylamine combined with polyoxyethylene surfactants and aromatic solvents forms stable oil-in-water emulsions and enhances leaf penetration.
• Acetochlor herbicide emulsion: Tri-n-octylamine with fatty alcohols and surfactants produces uniform particle dispersion and improves spraying performance.
• Cationic surfactant production: Tri-n-octylamine reacts with alkyl halides at 60–80 °C to generate quaternary ammonium salts used as bactericidal, antistatic, and softening agents.
• Non-ionic surfactant synthesis: ethoxylation of Tri-n-octylamine under alkaline catalysis yields polyoxyethylene amines that act as emulsifiers for detergents and industrial cleaners.
• Cutting-fluid formulation: low-dosage Tri-n-octylamine (1–3%) provides corrosion inhibition, lubrication improvement, and pH stabilization in synthetic metalworking fluids.
• Composite rust-preventive oil: blends containing Tri-n-octylamine, barium sulfonates, and borate esters form durable films that protect steel during storage and machining.
• Oilfield acidizing corrosion inhibitor: Tri-n-octylamine combined with acetylenic alcohols and iodides creates strong adsorption films that maintain steel integrity in HCl environments.
• Enhanced-oil-recovery surfactant: mixtures of Tri-n-octylamine with petroleum sulfonates and alcohols reduce interfacial tension and increase crude-oil displacement efficiency.
• Rubber vulcanization aid: Tri-n-octylamine in accelerator systems improves sulfur dispersion and increases cross-linking speed during curing.
• Textile finishing softener: quaternized Tri-n-octylamine at 10–20% reduces surface resistivity and enhances softness on synthetic fibers.
• Lithium-battery electrolyte additive: 0.1–2% Tri-n-octylamine enhances ionic conductivity and stabilizes charge–discharge cycling.
• Mineral flotation collector: 5–15% Tri-n-octylamine with fatty acids and sulfonates selectively adsorbs on mineral surfaces to boost recovery efficiency.
• Fertilizer anti-caking formulation: Tri-n-octylamine blended with fatty components prevents agglomeration and improves storage stability under humidity.

Packaging

• 200 kg iron drum
• 160 kg drum
• Customized packaging available upon request