1-Methylpyrrolidine NMPD N-Methylpyrrolidine CAS 120-94-5

Tree Chem 1-Methylpyrrolidine (NMPD) is a colorless to slightly yellow transparent liquid with a characteristic amine odor. Produced under strictly controlled hydrogenation and purification processes, it exhibits high purity, low moisture, and low THF and pyrrolidine residues.

We manufacture and supply NMPD for pharmaceutical and pesticide intermediates, alkylation reactions, ionic liquids, and polymer catalysts, with consistent product quality and full documentation support. For more details, contact info@cntreechem.com.

Specification

Basic Information

Technical Specification

Applications

Pharmaceutical Industry

• 1-Methylpyrrolidine (1-MP, CAS 120-94-5) is a crucial intermediate widely used in pharmaceutical manufacturing. Its five-membered heterocyclic structure and strong basicity make it ideal for constructing β-lactam, amide, and heterocyclic skeletons in complex molecules. The most significant pharmaceutical application of 1-MP is as a key intermediate in the synthesis of Cefepime, a fourth-generation cephalosporin antibiotic with broad-spectrum antibacterial activity and resistance to β-lactamase degradation. The synthetic pathway typically involves nucleophilic substitution of halogenated intermediates using 1-MP, resulting in yields above 90% and high purity.
• Beyond antibiotics, 1-MP is also applied in the synthesis of antidepressants such as sertraline and fluoxetine, and antihistamines like loratadine and cetirizine. It participates in catalytic hydrogenation, alkylation, and condensation reactions, forming N-alkyl substituted amines essential for active pharmaceutical ingredients. Additionally, it serves as a solvent or permeation enhancer in transdermal drug delivery systems, improving drug solubility and skin absorption by interacting with stratum corneum lipids.

Agrochemical Industry

• In the agrochemical field, 1-Methylpyrrolidine acts as both an intermediate and formulation solvent. It plays an essential role in the synthesis of novel herbicides and fungicides, especially in the development of Dimepyrolimet, a next-generation pyrrolidone amide herbicide introduced in 2024. This compound features a 1-Methylpyrrolidine moiety that enhances bioavailability and stability. 1-MP also participates in the formation of key intermediates for pyrazole sulfonylurea herbicides, demonstrating excellent chemical selectivity and high reactivity under mild conditions.
• As a formulation solvent, 1-MP is incorporated in emulsifiable concentrates (EC), suspension concentrates (SC), and microemulsions (ME) to improve pesticide solubility, dispersion, and field stability. In EC formulations, its concentration ranges from 0.5–10%, ensuring enhanced wetting and consistent droplet distribution. In ME systems, 5–15% of 1-MP increases miscibility between aqueous and oil phases, enabling stable and efficient pesticide performance.

Battery and Energy Industry

• 1-Methylpyrrolidine is increasingly important in lithium and zinc-ion battery technologies. It serves as a precursor for pyrrolidinium-based ionic liquids, such as [Pyr13][TFSI] and [Pyr14][TFSI], which possess wide electrochemical windows (>5.0 V), excellent thermal stability, and non-flammability. These ionic liquids are vital for improving high-voltage and high-temperature lithium battery performance.
• In zinc-ion batteries, 1-MP–derived ionic liquids form functional electrolytes that suppress dendrite growth and corrosion, significantly extending cycle life. Moreover, it acts as a co-solvent in gel polymer electrolytes (GPEs) based on PVDF, enhancing ionic conductivity (up to 10⁻³ S/cm) and mechanical stability. Such characteristics make it valuable for advanced energy-storage applications, including EV batteries and solid-state electrolyte systems.

Coatings and Ink Industry

• As a high-boiling solvent, 1-Methylpyrrolidine exhibits excellent solvency for resins such as epoxy, polyurethane, and acrylics, making it ideal for industrial coating systems. In epoxy coatings, 5–10% 1-MP improves viscosity control, adhesion, and leveling, ensuring smooth film formation and enhanced corrosion resistance. In polyurethane coatings, it contributes to gloss, flexibility, and mechanical durability, particularly for marine and automotive finishes.
• In the ink sector, 1-MP functions as a solvent for solvent-based and specialty inks, including conductive and UV-curable formulations. Its high boiling point and moderate evaporation rate improve pigment dispersion and print sharpness, while its compatibility with other organic solvents prevents phase separation. Typical concentrations range between 10–25%, balancing open time and fast drying properties.

Electronics and Semiconductor Industry

• Due to its high purity and excellent solvation capacity, 1-Methylpyrrolidine is used in photoresist stripping, semiconductor cleaning, and PCB fabrication. It effectively removes organic contaminants and residues from wafer surfaces and circuit boards. Electronic-grade 1-MP must reach ≥99.99% purity, with metallic impurities controlled at the ppb level to prevent interference in microfabrication. It is commonly used in stripping agents containing NMP (20–75%), γ-butyrolactone (35–40%), and chelating additives, achieving over 95% cleaning efficiency without damaging substrates.

Fragrance and Fine Chemicals Industry

• 1-MP is a versatile building block for flavor and fragrance intermediates, imparting smooth, nutty, or roasted notes in aroma formulations. It is used in both food flavoring and cosmetic fragrance synthesis as a nitrogen-containing heterocyclic precursor, contributing to molecules with enhanced odor stability. Additionally, it acts as a solvent for fragrance blending, providing excellent miscibility with essential oils and resins.

New Materials and Polymers

• In polymer chemistry, 1-MP contributes to the development of biodegradable materials and specialty surfactants. Its derivatives can polymerize to form poly(α-acetyl-γ-butyrolactone)-type materials, which are biocompatible and bioabsorbable, suitable for medical implants and tissue engineering. In surfactant design, 1-MP introduces amphiphilic balance, resulting in low-foam, high-efficiency cleaning agents for precision components and 3D printing applications.

Storage & Handling

• Store in cool, dry, and ventilated areas, away from heat and open flames.
• Keep containers tightly closed and prevent contact with air and moisture.
• Avoid contact with oxidants and acids.
• Recommended storage temperature: below 30 °C.
• Use galvanized or stainless steel drums for long-term storage.

Usage Notice

• Handle with protective gloves, goggles, and face masks.
• Avoid prolonged inhalation and direct contact with skin or eyes.
• Ensure good ventilation and grounding during transfer operations.
• Dispose of any residues according to local hazardous chemical regulations.
• Prevent contamination with strong oxidizers to avoid hazardous reactions.
• In the pharmaceutical intermediate synthesis for Cefepime, a mixture of 10 g GCLE and 2.35 mL 1-Methylpyrrolidine in dichloromethane is reacted at −10 °C for 1 hour to obtain 92 % yield and at least 80 % purity.
• In antidepressant production, 1-Methylpyrrolidine at 10–30 mol % acts as a key amine source together with formaldehyde and catalyst to form the intermediate for Sertraline and Fluoxetine.
• In a transdermal patch system, 5–15 % active drug, 30–50 % adhesive, and 3–20 % 1-Methylpyrrolidine are combined to enhance skin permeability and improve drug release performance.
• For herbicide synthesis such as Dimepyrolimet, pure 1-Methylpyrrolidine serves as the base reagent that constructs the pyrrolidone amide moiety under mild reaction conditions.
• In pesticide formulations of emulsifiable concentrates, 10–60 % active ingredient, 30–60 % organic solvent, 0.5–10 % 1-Methylpyrrolidine, and 5–15 % emulsifier are used to improve wetting and stability in field applications.
• As a battery electrolyte additive, a mixture of 64–80 % Pyr14TFSI, 12–27 % lithium salt, and 0.5–8 % 1-Methylpyrrolidine is prepared to enhance ionic conductivity and thermal stability in high-voltage cells.
• In epoxy coatings, 60–70 % epoxy resin, 10–15 % curing agent, and 5–10 % 1-Methylpyrrolidine are blended to increase film adhesion, smoothness, and corrosion resistance.
• For ink formulation, 15–25 % pigment, 20–30 % resin, and 10–25 % 1-Methylpyrrolidine are combined with solvents to achieve stable dispersion and high-definition printing.
• In photoresist stripping, a composition of 20–75 % NMP, 35–40 % γ-butyrolactone, and a small amount of 1-Methylpyrrolidine removes more than 95 % of organic residues without damaging substrates.
• In flavor compound blends, 85–90 % aroma materials, 5–10 % 1-Methylpyrrolidine, and 1–3 % fixative are mixed to enhance diffusion and extend the longevity of fragrance notes.

Packaging

• 140 kg galvanized steel drum
• Custom packaging available upon request