Dodecylamine DDA Laurylamine CAS 124-22-1
- CAS: 124-22-1
- Synonyms: Dodecylamine; n-Dodecylamine; Laurylamine; 1-Dodecanamine; Primary dodecyl amine; DDA
- EINECS No.: 204-690-6
- Molecular Formula: C₁₂H₂₇N
- Grade: Industrial Grade
- Packaging: 160 kg iron drum / plastic drum
Tree Chem manufactures Dodecylamine (CAS 124-22-1) for customers looking to purchase high-purity primary amines for use in surfactants, flotation chemicals, lubricants, agrochemical intermediates, and specialty chemical formulations. Our Dodecylamine is a colorless to pale yellow liquid at normal temperature and is produced under controlled distillation steps to ensure consistent purity, stable chain distribution, and reliable performance in downstream reactions.
Tree Chem supplies stable drum quantities and offers documentation support for industrial customers. With ≥98% assay, controlled amine value, low moisture, and clean color levels, our material is suitable for synthesis, formulation work, and general industrial applications. For inquiries or quotations, please contact info@cntreechem.com.
Specification
Basic Information
| Parameter | Value |
| Product Name | Dodecylamine |
| CAS No. | 124-22-1 |
| EINECS No. | 204-690-6 |
| Molecular Formula | C₁₂H₂₇N |
| Molecular Weight | 185.35 |
| Appearance | Colorless to pale yellow liquid |
| Synonyms | n-Dodecylamine; Laurylamine; Primary dodecyl amine; 1-Dodecanamine; DDA |
| Packaging | 160 kg iron drum / 160 kg plastic drum (customized packaging available) |
Technical Specification
| Item | Specification |
| Appearance | Colorless to pale yellow liquid |
| Assay | ≥98% |
| Total Amine Value | 295–305 mgKOH/g |
| Color | ≤30 APHA |
| Moisture | ≤0.3% |
| Carbon Chain (C12) | ≥97% |
Applications
Pharmaceutical Industry
- Dodecylamine serves as an important intermediate for antibiotic, anesthetic, and antiparasitic synthesis. In antibiotic manufacture, it is involved in building the side-chain of enrofloxacin and similar fluoroquinolone drugs, improving antibacterial strength and lipophilicity. It is also used in producing dibucaine, a long-acting local anesthetic, where the C₁₂ chain contributes to prolonged nerve-block duration and reduced systemic absorption.
- As a functional auxiliary, dodecylamine acts as a carrier, emulsifier, and slow-release regulator in formulations. Its amphiphilic nature allows efficient dispersion of poorly soluble actives in oral and topical dosage forms. Derivatives of dodecylamine—especially quaternary ammonium compounds—exhibit sterilizing power and are applied as disinfectants for medical equipment and surfaces. In these formulations, it works synergistically with benzalkonium or dialkyl ammonium chlorides to provide high-level disinfection.
- In synthetic chemistry, dodecylamine also performs as a phase-transfer catalyst, enhancing reaction selectivity and yield in multi-phase pharmaceutical reactions, especially where nucleophilic substitution or condensation is required.
Agrochemical Industry
- The agrochemical sector represents the largest consumer of dodecylamine, accounting for nearly half of total demand. It is primarily employed as a herbicide emulsifier, forming stable oil-in-water emulsions that ensure even distribution of active ingredients like glyphosate or acetochlor.
- In glyphosate systems, 5–15 % dodecylamine combined with sulfonates and polyether dispersants reduces interfacial tension and maintains phase stability during storage and spraying. Similarly, in acetochlor emulsifiers it works alongside alcohols and surfactants to enhance suspension quality and penetration on plant surfaces.
- In pesticide synthesis, dodecylamine reacts with thiocarbonyl compounds to form thiocarbamate intermediates—precursors for organophosphorus insecticides—and acts as a synergist in pyrethroid formulations by inhibiting pest detoxification enzymes. Moreover, quaternary derivatives such as dodecyl dimethyl benzyl ammonium chloride serve as broad-spectrum bactericides and seed treatments.
Surfactant Industry
- Dodecylamine is the key building block for cationic, non-ionic, and amphoteric surfactants.
- Cationic derivatives—produced by quaternization with methyl or benzyl halides—yield compounds such as dodecyl trimethyl ammonium bromide and benzalkonium chlorides, which display excellent bactericidal, antistatic, and softening properties. These are used in household cleaners, personal-care products, and textile finishing.
- In non-ionic surfactant manufacture, ethoxylation of dodecylamine with ethylene oxide (120–180 °C, alkaline catalysis) gives polyoxyethylene dodecylamines with tunable HLB values. These find broad use in detergents, shampoos, cosmetics, and industrial degreasers, offering strong emulsification and mildness.
- Amphoteric surfactants such as betaine and imidazoline types are also synthesized from dodecylamine. These molecules retain stability under both acidic and alkaline conditions, showing outstanding compatibility in complex formulations like shampoos, agrochemical emulsions, and tertiary-oil-recovery fluids.
Metalworking and Corrosion Control
- In the metal-processing industry, dodecylamine and its salts act as pH regulators, lubricants, corrosion inhibitors, and anti-rust components.
- In synthetic cutting fluids, 10–25 % dodecylamine provides alkalinity and passivation of ferrous metals, while in semi-synthetic systems it balances emulsification, lubrication, and cooling efficiency. Reaction with organic acids such as oleic or sulfonic acids yields dodecylamine oleate or sulfonate salts that form stable protective films on steel surfaces.
- It also appears in composite rust-preventive oils with triethanolamine borate and barium sulfonate, delivering more than twelve-month protection under humid conditions. Its dual physical and chemical adsorption mechanism decreases corrosion current density by over two orders of magnitude.
Petrochemical and Oilfield Applications
- Dodecylamine participates in formulating acidizing corrosion inhibitors for oil and gas wells. Through a Mannich reaction with acetophenone and formaldehyde, it generates bis-Mannich-base inhibitors showing >95 % protection at 180 °C. These inhibitors maintain film integrity in HCl and CO₂ environments.
- It is also used as an emulsifier and stabilizer in drilling fluids, improving lubrication and filtrate control, and as a feedstock for surfactant systems enhancing tertiary oil recovery. The reaction of dodecylamine with propylene oxide forms surface-active products that increase crude-oil yield by 10–15 %.
Rubber and Polymer Industry
- Dodecylamine functions as a vulcanization accelerator, activator, and antioxidant precursor. It promotes dispersion of zinc oxide and sulfur in rubber, improving cross-linking rate and mechanical strength.
- Its derivatives also serve as process aids that reduce compound viscosity during extrusion and molding, while some act as stabilizers that prevent premature curing and oxidative degradation. Formulations containing 5–10 % dodecylamine, carbon disulfide, and alkali solution achieve a 20–30 % increase in curing speed.
Textile and Leather Processing
- Quaternary ammonium compounds derived from dodecylamine are widely used as antistatic agents and softeners for synthetic fibers. They lower surface resistivity to 10⁸–10⁹ Ω, prevent static buildup, and provide lasting softness even after repeated washing.
- In textile dyeing, dodecylamine derivatives serve as leveling agents and wetting agents, ensuring even color distribution and better dye penetration. For leather finishing, amide derivatives impart smoothness and water resistance, while fluorinated derivatives are employed in durable water-repellent coatings.
Electronics and High-Tech Applications
- Dodecylamine finds increasing use in electronics manufacturing. It acts as a precursor to liquid-crystal materials for TN, STN, and TFT-LCD displays, controlling molecular alignment and phase stability. It is also utilized as a mild electronic-component cleaner, capable of removing grease and metal residues without corrosion.
- In emerging new-energy applications, dodecylamine functions as an electrolyte additive in lithium-ion batteries to improve ionic conductivity and cycle stability. It can also serve as a surface modifier in solar-cell panels, boosting photoelectric conversion efficiency, and as a template agent for nanomaterial synthesis and dispersion.
Other Industrial Uses
- In mineral flotation, dodecylamine operates as a collector to separate sulfide and oxide ores of copper, zinc, and lead, typically in 5–15 % dosage with fatty acids and petroleum sulfonates. It enhances recovery efficiency and froth stability.
- In fertilizer production, it is incorporated into anti-caking agents (10–30 %) together with mono-glycerides and long-chain fatty acids to maintain free-flowing granular fertilizers under humid storage.
- It also serves as a pigment dispersant in coatings and inks, lowering system viscosity by 30–50 % and improving color uniformity, and as a lubricant additive providing dispersancy and anti-oxidation to protect mechanical parts.
Storage & Handling
- Store in sealed containers in a cool, dry, ventilated area
- Keep away from heat, sunlight, and ignition sources
- Avoid contact with acids and strong oxidizers
- Use proper gloves, goggles, and ventilation
- Recommended storage temperature: below 30°C
Usage Notice
- Avoid skin and eye contact; rinse with water if contact occurs
- Operate in ventilated spaces to avoid vapor accumulation
- Prevent leakage during transfer
- Dispose of waste according to local environmental regulations
- Keep container tightly closed after use
- Pharmaceutical disinfectant formula: 1 % didecyl dimethyl ammonium chloride and 1.6 % dodecyl dimethyl benzyl ammonium chloride—derived from dodecylamine—are diluted 1:100 for surface sterilization in medical facilities.
- Antibiotic intermediate synthesis: dodecylamine reacts with halogenated precursors to construct the hydrophobic side-chain in enrofloxacin intermediates, enhancing bioavailability and antibacterial activity.
- Glyphosate herbicide emulsion: 5–15 % dodecylamine combined with calcium dodecylbenzenesulfonate and polymeric carboxylates stabilizes the oil-in-water phase, providing lasting suspension and field persistence.
- Acetochlor herbicide emulsion: a blend containing 5–15 % dodecylamine with xylene, acrylic acid, and fatty alcohols produces uniform particle dispersion and improves herbicidal spreading.
- Cationic surfactant production: dodecylamine is quaternized with methyl or benzyl halides at 60–80 °C to form quaternary ammonium salts that act as antistatic and softening agents for textiles and disinfectants.
- Non-ionic surfactant synthesis: reaction with ethylene oxide under alkaline conditions creates polyoxyethylene dodecylamine, a non-ionic emulsifier for cleaners and personal-care products.
- Cutting-fluid formulation: containing 10–25 % dodecylamine as an alkaline component provides corrosion inhibition and pH buffering in synthetic metalworking fluids.
- Composite rust-preventive oil: a mixture of 10–20 parts triethanolamine borate, 5–10 parts barium sulfonate, and 5–10 parts dodecylamine forms durable protective films on metal surfaces.
- Oilfield acidizing corrosion inhibitor: a Mannich base from dodecylamine, acetophenone, and formaldehyde (1 : 1.3 : 1.3 mole ratio) achieves > 95 % protection efficiency at 180 °C in acidic environments.
- Rubber vulcanization aid: 5–10 parts dodecylamine combined with carbon disulfide and alkali solution accelerates cross-linking and increases curing speed by 20–30 %.
- Textile finishing softener: quaternized dodecylamine (10–20 %) reduces surface resistivity to 10⁸–10⁹ Ω and gives lasting softness on synthetic fibers.
- Lithium-battery electrolyte additive: 0.1–2 % dodecylamine enhances ionic conductivity and stabilizes charge–discharge cycles in high-energy cells.
- Mineral flotation collector: 5–15 % dodecylamine with fatty acids and sulfonates selectively adsorbs on ore surfaces to increase recovery and reduce flotation loss.
- Fertilizer anti-caking agent: 10–30 % dodecylamine combined with mono-glycerides and fatty acids prevents clumping and improves storage stability under high humidity.
Packaging
- 160 kg iron drum
- 160 kg plastic drum
- Customized packaging available




